Is High-Dose Platelet-Rich Plasma (PRP) Better for Treating Knee Osteoarthritis?
If you’re struggling with knee osteoarthritis (OA), you may have heard about platelet-rich plasma (PRP) therapy as a way to reduce pain and improve movement. PRP uses platelets from your own blood to help repair damaged tissue, but did you know that the dose of PRP can make a difference? Here’s what you need to know about how high-dose PRP compares to standard doses for knee arthritis.
What Is PRP Therapy?
PRP is made by taking a sample of your blood, spinning it in a machine to concentrate the platelets, and injecting it into your knee. These platelets are packed with healing factors that can reduce inflammation, repair tissue, and ease pain. PRP has become a popular treatment for knee OA because it’s minimally invasive and uses your body’s natural healing power.
High-Dose vs. Standard PRP: What's the Difference?
The key difference between high-dose and standard PRP is the number of platelets in each injection. High-dose PRP typically has twice as many platelets as standard PRP. Research shows that this difference can lead to better results for some patients.
Better Pain Relief with High-Dose PRP
A study comparing high-dose (8 mL) and standard-dose (4 mL) PRP found that patients who received the high dose experienced greater pain relief and improved knee function. After six months, 96% of patients who got high-dose PRP were satisfied, compared to 68% of those who received the standard dose (Patel et al., 2024).Longer-Lasting Benefits
High-dose PRP also seems to last longer. One study showed that patients with mild-to-moderate arthritis who received high-dose PRP reported less pain and better movement for up to 12 months, while results with standard PRP often faded after six months (De Matthaeis et al., 2024).More Protection for Your Knee
High-dose PRP may help protect your knee joint by reducing inflammation and slowing cartilage damage. Researchers have found that patients receiving high-dose PRP showed reduced markers of inflammation and better functional scores at one year compared to those who received lower doses (Bansal et al., 2021).Are There Any Downsides?
High-dose PRP may cause short-term side effects like mild pain or stiffness after the injection, but these symptoms usually go away within a few days. Both high-dose and standard PRP are considered safe because they use your own blood, minimizing the risk of rejection or serious complications (Patel et al., 2024).
Which Option Is Right for You?
Choosing between high-dose and standard PRP depends on your condition and goals. Here’s a quick guide:
For longer-lasting results: High-dose PRP may be better, especially if you have mild-to-moderate OA.
For minimal side effects: Standard PRP is a great option with fewer post-injection reactions.
For early-stage arthritis: High-dose PRP could give you an extra edge in preserving your joint health.
Takeaway
PRP is a powerful option for treating knee osteoarthritis, and high-dose PRP often provides better and longer-lasting results. Whether you choose high-dose or standard PRP, this therapy could help you reduce pain, move more comfortably, and avoid surgery.
Dr. Goodman is passionate about offering personalized solutions to keep patients active and moving.
